pramlintide   Click here for help

GtoPdb Ligand ID: 7482

Synonyms: AC0137 | Symlin®
Approved drug
pramlintide is an approved drug (FDA (2005))
Comment: Pramlintide is an analogue of human amylin, with prolines replacing the native amino acids at positions 25, 28 and 29. The marketed medicine is the acetate salt (PubChem CID 16132446). ChEMBL also represents the acetate form with the record CHEMBL1201669.
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Summary of Clinical Use Click here for help
Used as an adjunctive therapy for patients with either type 1 or type 2 diabetes [2] with poor glycemic control using insulin.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The neuroendocrine hormone amylin acts in conjunction with insulin to delay gastric emptying and inhibit the release of glucagon. Pramlintide mimics this action [2].
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