pramlintide   Click here for help

GtoPdb Ligand ID: 7482

Synonyms: AC0137 | Symlin®
Approved drug
pramlintide is an approved drug (FDA (2005))
Compound class: Peptide
Comment: Pramlintide is an analogue of human amylin, with prolines replacing the native amino acids at positions 25, 28 and 29. The marketed medicine is the acetate salt (PubChem CID 16132446). ChEMBL also represents the acetate form with the record CHEMBL1201669.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
AMY1 receptor Hs Agonist Agonist 9.4 – 9.4 pEC50 - 1
pEC50 9.4 – 9.4 (EC50 4.36x10-10 – 3.55x10-10 M) [1]
Description: Measuring ligand-induced cAMP production in COS and HEK293 cells.
AMY3 receptor Hs Agonist Agonist 9.1 – 9.3 pEC50 - 1
pEC50 9.1 – 9.3 (EC50 8.91x10-10 – 5.2x10-10 M) [1]
Description: Measuring ligand-induced cAMP production in COS and HEK293 cells.
AMY2 receptor Hs Agonist Agonist 8.6 – 8.9 pEC50 - 1
pEC50 8.6 – 8.9 (EC50 2.29x10-9 – 1.38x10-9 M) [1]
Description: Measuring ligand-induced cAMP production in COS and HEK293 cells.
CT receptor Hs Agonist Agonist 8.3 pEC50 - 1
pEC50 8.3 (EC50 5.495x10-9 M) [1]
Description: Measuring ligand-induced cAMP in COS and KEK293 cells.
Ligand mentioned in the following text fields