zuclopenthixol   Click here for help

GtoPdb Ligand ID: 7559

Synonyms: Acuphase® | cis(Z)-cloflupentixol | Cisordinol® | Clopixol® | NSC 64087 | NSC169185
Approved drug
zuclopenthixol is an approved drug
Compound class: Synthetic organic
Comment: Zuclopenthixol is a thioxanthene class typical antipsychotic. Chemically it is the cis-isomer of clopenthixol. The CAS registry number (53772-83-1) submitted with the WHO INN record for zuclopenthixol maps to PubChem CID 5311507.
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View more information in the IUPHAR Pharmacology Education Project: zuclopenthixol

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 52.01
Molecular weight 400.14
XLogP 4.12
No. Lipinski's rules broken 0
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Canonical SMILES OCCN1CCN(CC1)CCC=C1c2ccccc2Sc2c1cc(Cl)cc2
Isomeric SMILES OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(Cl)cc2
InChI InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5-
No information available.
Summary of Clinical Use Click here for help
Used to treat schizophrenia and acute mania. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency (EMA) websites. Individual national approval agencies may have granted marketing authorisation. See Drugs.com for a list of countries where this drug may be in use. In the UK three salt formulations of zuclopenthixol are approved; acetate (PubChem CID 6436640, injectable form), decanoate (PubChem CID 6450333, injectable form) and dihydrochloride (PubChem CID 6433208), tablet form).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Zuclopenthixol is an antagonist of the dopamine D1 and D2 receptor subtypes. Drug treatment induces sedation and improves psychotic symptoms.
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