sacubitril

Ligand id: 7857

Name: sacubitril

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 92.7
Molecular weight 411.2
XLogP 3.86
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In 2015, the EMA and FDA approved the fixed-dose combination Entresto® (sacubitril plus valsartan) to treat heart failure. Sacubitril is not approved as a monotherapy. Entresto® is reported to be superior to enalapril in reducing the risks of death and hospitalization for heart failure [1].