Ligand id: 7857

Name: sacubitril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 92.7
Molecular weight 411.2
XLogP 3.86
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K et al.. (2014)
Angiotensin-neprilysin inhibition versus enalapril in heart failure.
N. Engl. J. Med., 371 (11): 993-1004. [PMID:25176015]