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Synonyms: AHU377 | Entresto® | Neparvis®
sacubitril is an approved drug (EMA & FDA (2015))
Compound class: Synthetic organic
Comment: Sacubitril is a prodrug activated by de-ethylation via esterases to the neprilysin inhibitor sacubitrilat. Neprilysin is also known as neutral endopeptidase (NEP), and its official gene symbol is MME (membrane metallo-endopeptidase ). The chemical database relationships are detailed in this blogpost. Sabucatril is a component of the approved fixed mixture Entresto®, previously known as LCZ696, and which is now approved for heart failure (see Clinical data tab).