periciazine   Click here for help

GtoPdb Ligand ID: 9216

Synonyms: pericyazine | propericiazine | RP-8909
Approved drug
periciazine is an approved drug (UK (2009))
Compound class: Synthetic organic
Comment: Periciazine is a phenothiazine antipsychotic. It has anti-dopaminergic, adrenolytic, anticholinergic, metabolic and endocrine effects.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 75.8
Molecular weight 365.16
XLogP 3.86
No. Lipinski's rules broken 0
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Canonical SMILES N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1
Isomeric SMILES N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1
InChI InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
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Summary of Clinical Use Click here for help
Approved in the UK for the management of schizophrenia or other psychoses, and as short-term adjunctive management of severe anxiety, psychomotor agitation, and violent or dangerously impulsive behaviour.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The precise molecular mechanism of action is poorly defined, but is thought in involve antagonism of central dopamine receptors [1] and adrenoceptors [2].
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