periciazine   Click here for help

GtoPdb Ligand ID: 9216

Synonyms: pericyazine | propericiazine | RP-8909
Approved drug
periciazine is an approved drug (UK (2009))
Compound class: Synthetic organic
Comment: Periciazine is a phenothiazine antipsychotic. It has anti-dopaminergic, adrenolytic, anticholinergic, metabolic and endocrine effects.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 75.8
Molecular weight 365.16
XLogP 3.86
No. Lipinski's rules broken 0
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Canonical SMILES N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1
Isomeric SMILES N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1
InChI InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
1. Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E. (1994)
Affinity of neuroleptics for D1 receptor of human brain striatum.
J Psychiatry Neurosci, 19 (4): 265-9. [PMID:7918347]
2. Tsukamoto T, Asakura M, Hirata N, Imafuku J, Matsui H, Hasegawa K. (1984)
Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action.
Biol Psychiatry, 19 (9): 1283-91. [PMID:6149771]