Ligand id: 9850

Name: GW406381

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 81.94
Molecular weight 393.11
XLogP 4.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
GW406381 has completed Phase 3 clinical evaluation in knee osteoarthritis [2], rheumatoid arthritis, and post-dental surgery pain (clinically meaningful analgesia was demnostrated in this acute pain setting, but time to onset was >1 hour) [3].