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Synonyms: compound 8 [PMID: 15454242] | GW-406381
Compound class: Synthetic organic
Comment: GW406381 is a cyclooxygenase inhibitor that is selective for the COX2 isozyme, that has clinical potential for the treatment of inflammatory pain .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|COX2 selective inhibitors have demonstrated clinical efficacy equivalent to NSAIDs in the treatment of inflammatory pain, but are not associated with the gastrointestinal toxicity typical of NSAID use.
|Phase 3 clinical candidate for RA- see NCT00113308.
|Phase 3 clinical candidate for OA- see NCT00120900. However GW406381 failed to demonstrate clinically meaningful efficacy in pain related to OA of the knee.