rabeximod   Click here for help

GtoPdb Ligand ID: 9856

Synonyms: Rob-803 | Rob803
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Rabeximod is an orally active immunomodulator. It has potent anti-rheumatic effects in animal models and is being evaluated as a potential drug for rheumatoid arthritis patients. The structure was originally claimed in patent WO2005123741A1 (Compound E) for anti-inflammatory potential [1], and later for antiviral potential in patent WO2014140321A1 (example 2). The molecular mechanism of action of this compound vis its anti-inflammatory activity remains unclear.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 63.05
Molecular weight 409.17
XLogP 4.11
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCNC(=O)Cn1c2ccc(cc2c2c1nc1cc(C)c(cc1n2)C)Cl)C
Isomeric SMILES CN(CCNC(=O)Cn1c2ccc(cc2c2c1nc1cc(C)c(cc1n2)C)Cl)C
InChI InChI=1S/C22H24ClN5O/c1-13-9-17-18(10-14(13)2)26-22-21(25-17)16-11-15(23)5-6-19(16)28(22)12-20(29)24-7-8-27(3)4/h5-6,9-11H,7-8,12H2,1-4H3,(H,24,29)
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Summary of Clinical Use Click here for help
Phase 2 clinical trial NCT00525213 that was evaluating rabeximod (Rob 803) in patients with moderate or severe active rheumatoid arthritis has been completed, but results have not been published in peer reviewed literature.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00525213 Study to Evaluate the Efficacy and Safety of Orally Administered Rob 803 When Added to Methotrexate Phase 2 Interventional OxyPharma