rabeximod   Click here for help

GtoPdb Ligand ID: 9856

Synonyms: Rob-803 | Rob803
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Rabeximod is an orally active immunomodulator. It has potent anti-rheumatic effects in animal models and is being evaluated as a potential drug for rheumatoid arthritis patients. The structure was originally claimed in patent WO2005123741A1 (Compound E) for anti-inflammatory potential [1], and later for antiviral potential in patent WO2014140321A1 (example 2). The molecular mechanism of action of this compound vis its anti-inflammatory activity remains unclear.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 63.05
Molecular weight 409.17
XLogP 4.11
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCNC(=O)Cn1c2ccc(cc2c2c1nc1cc(C)c(cc1n2)C)Cl)C
Isomeric SMILES CN(CCNC(=O)Cn1c2ccc(cc2c2c1nc1cc(C)c(cc1n2)C)Cl)C
InChI InChI=1S/C22H24ClN5O/c1-13-9-17-18(10-14(13)2)26-22-21(25-17)16-11-15(23)5-6-19(16)28(22)12-20(29)24-7-8-27(3)4/h5-6,9-11H,7-8,12H2,1-4H3,(H,24,29)
1. Bergman J, Engqvist R, Gerdin B, Kihlström I, Björklumd U. (2005)
Alkyl substituted indoloquinoxalines.
Patent number: WO2005123741. Assignee: Oxypharma Ab. Priority date: 17/06/2004. Publication date: 29/12/2005.
2. Giusti P, Frascaroli G, Tammik C, Gredmark-Russ S, Söderberg-Nauclér C, Varani S. (2011)
The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages.
Immunobiology, 216 (1-2): 243-50. [PMID:20494473]
3. Westman E, Thi Ngoc DD, Klareskog L, Harris HE. (2008)
Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis.
Clin Exp Immunol, 152 (1): 192-9. [PMID:18307516]