rabeximod

Ligand id: 9856

Name: rabeximod

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 63.05
Molecular weight 409.17
XLogP 4.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-(9-chloro-2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide
International Nonproprietary Names
INN number INN
8866 rabeximod
Synonyms
Rob-803 | Rob803
Comments
Rabeximod is an orally active immunomodulator. It has potent anti-rheumatic effects in animal models and is being evaluated as a potential drug for rheumatoid arthritis patients. The structure was originally claimed in patent WO2005123741A1 (Compound E) for anti-inflammatory potential [1], and later for antiviral potential in patent WO2014140321A1 (example 2). The molecular mechanism of action of this compound vis its anti-inflammatory activity remains unclear.
Database Links
CAS Registry No. 872178-65-9 (source: WHO INN record)
DrugBank Ligand DB05772
GtoPdb PubChem SID 363894150
PubChem CID 56841552
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