compound 7d [PMID: 29672049]

Ligand id: 9937

Name: compound 7d [PMID: 29672049]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 106.15
Molecular weight 490.32
XLogP 3.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Compound 7d inhibits FLT3 autophosphorylation and down modulates its downstream signaling pathways. This action ultimately leads to cell cycle arrest and apoptosis of FLT3-ITD positive MV4-11 cells.