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Synonyms: platelet factor 4 (PF4)
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CXCL4 is a C-X-C motif chemokine first identified in megakaryocytes and platelets. It is a potent antiangiogenic chemokine and also promotes inflammatory fibrosis [3]. It can be used as a prognostic marker for the fibrosing autoimmune disease systemic sclerosis (scleroderma) [2]. A CXCR3 splice variant, CXCR3B, is a functional receptor for CXCL4 [1].
Species: Human
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| Immunopharmacology Comments |
| Plasmacytoid dendritic cell-derived CXCL4 is involved in the pathogenesis of systemic sclerosis. In vitro, CXCL4 induces the secretion of endothelin 1 by human endothelial cells, and in vivo (in mice) promotes expression of highly proinflammatory CCL2, infiltration of inflammatory cells to sites of CXCL4 injection and induces dermal thickening [2]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Scleroderma |
Disease Ontology:
DOID:419 |
CXCL4 levels correlate with skin and lung fibrosis in patienst with scleroderma, and is he only chemokine whose level is predictedive of the risk and progression of scleroderma. | 2 |
