CXCL4   Click here for help

GtoPdb Ligand ID: 3685

Synonyms: platelet factor 4 (PF4)
Immunopharmacology Ligand
Comment: CXCL4 is a C-X-C motif chemokine first identified in megakaryocytes and platelets. It is a potent antiangiogenic chemokine and also promotes inflammatory fibrosis [3]. It can be used as a prognostic marker for the fibrosing autoimmune disease systemic sclerosis (scleroderma) [2]. A CXCR3 splice variant, CXCR3B, is a functional receptor for CXCL4 [1].
Species: Human
1. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E et al.. (2003)
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
J Exp Med, 197 (11): 1537-49. [PMID:12782716]
2. van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M et al.. (2014)
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.
N Engl J Med, 370 (5): 433-43. [PMID:24350901]
3. Zaldivar MM, Pauels K, von Hundelshausen P, Berres ML, Schmitz P, Bornemann J, Kowalska MA, Gassler N, Streetz KL, Weiskirchen R et al.. (2010)
CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis.
Hepatology, 51 (4): 1345-53. [PMID:20162727]