Ligand id: 7906

Name: bafetinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 99.17
Molecular weight 576.26
XLogP 3.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Bafetinib is included in GtoImmuPdb based on its potential clinical utility as a treatment for leukemia.
Immunopharmacology Disease
Disease X-Refs Comment References
B-cell chronic lymphocytic leukemia OMIM: 151400
Orphanet: ORPHA67038
FDA and EMA orphan drug for Philadelphia chromosome-positive CML. Phase 2 clinical trial in B cell CLL has been completed (see NCT01144260).