adriforant

Ligand id: 8985

Name: adriforant

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 79.1
Molecular weight 262.19
XLogP 1.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
ZPL-3893787 is an invesitgational selective histamine H4 receptor antagonist that is being developed for anti-inflammatory potential in the treatment of dermatological inflammation.
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
Completed Phase 2 trial in psoriasis (see NCT02618616).
Atopic dermatitis Disease Ontology: DOID:3310
OMIM: 603165
Completed Phase 2 trial in atopic dermatitis (see NCT02424253). Improvement in inflammatory AD lesions in response to ZPL-3893787 treatment in clinical trial was reported by Werrfel et al. (2018) 3