Ligand id: 9772

Name: lenabasum

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 66.76
Molecular weight 400.26
XLogP 6.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Ajulemic acid is being investigated as a potential treatment for chronic inflammation [2]. It has been shown to attenuate the inflammatory response in murine collagen-induced arthritis and rat adjuvant arthritis models [1,7].
Immunopharmacology Disease
Disease X-Refs Comment References
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
Phase 2 clinical candidate for SLE- see NCT03093402
Systemic scleroderma Disease Ontology: DOID:418
OMIM: 181750
Orphanet: ORPHA90291
A Phase 3 multicenter trial to evaluate AJA's safety and efficacy in SSc has recently been initiated- see NCT03398837