lenabasum

Ligand id: 9772

Name: lenabasum

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 66.76
Molecular weight 400.26
XLogP 6.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Burstein S. (2005)
Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials.
AAPS J, 7 (1): E143-8. [PMID:16146336]
2. Burstein SH. (2018)
Ajulemic acid: potential treatment for chronic inflammation.
Pharmacol Res Perspect, 6 (2): e00394. [PMID:29638269]
3. Burstein SH, Karst M, Schneider U, Zurier RB. (2004)
Ajulemic acid: A novel cannabinoid produces analgesia without a "high".
Life Sci., 75 (12): 1513-22. [PMID:15240185]
4. Han S, Thatte J, Buzard DJ, Jones RM. (2013)
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
J. Med. Chem., 56 (21): 8224-56. [PMID:23865723]
5. Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U. (2003)
Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.
JAMA, 290 (13): 1757-62. [PMID:14519710]
6. Rhee M-H, Vogel, Z, Barg J, Bayewitch M, Levy R, Hanu L, Breuer A., Mechoulam R. (1997)
Cannabinoid derivatives: binding to cannabinoid receptors and inhibition of adenylcyclase.
Journal of Medicinal Chemistry, 40: 3228−3233.
7. Sumariwalla PF, Gallily R, Tchilibon S, Fride E, Mechoulam R, Feldmann M. (2004)
A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.
Arthritis Rheum., 50 (3): 985-98. [PMID:15022343]
8. Vann RE, Cook CD, Martin BR, Wiley JL. (2007)
Cannabimimetic properties of ajulemic acid.
J. Pharmacol. Exp. Ther., 320 (2): 678-86. [PMID:17105826]