boromycin   Click here for help

GtoPdb Ligand ID: 13447

Antimalarial Ligand
Compound class: Natural product
Comment: Boromycin is a polyether macrolide, initially isolated from a new strain of Streptomyces antibioticus (ETH 28 829), and reported as the first boron-containing natural product to be identified [3-4]. It is a broad-spectrum antimicrobial compound, with potent activity against a number of Gram-positive bacteria, viruses, and protozoan parasites [1-2,4-5].

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 16
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 209.99
Molecular weight 878.87
XLogP 5.74
No. Lipinski's rules broken 3
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(C)[C@H](C(=O)O[C@H](C)[C@@H]1C/C=C/CC[C@@H](C(C)(C)[C@@H]2CC[C@@H](C)[C@]3(C4C(=O)O[C@H]5C[C@@H](CCC[C@H](C(C)(C)[C@@H]6CC[C@@H](C)[C@]7(C(C(=O)O1)O[B-](O4)(O7)O3)O6)O)O[C@@H]5C)O2)O)N
Isomeric SMILES [B-]123OC4C(=O)O[C@@H](C/C=C/CC[C@@H](C([C@@H]5CC[C@H]([C@@](O1)(O5)C(O2)C(=O)O[C@H]6C[C@@H](CCC[C@H](C([C@@H]7CC[C@H]([C@@]4(O3)O7)C)(C)C)O)O[C@@H]6C)C)(C)C)O)[C@@H](C)OC(=O)[C@@H](C(C)C)N
InChI InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37?,38?,44+,45+,46?/m1/s1
InChI Key OOBFYEMEQCZLJL-XURNZCJASA-N
Guide to Malaria Pharmacology Comments
Boromycin is a promising antimalarial candidate with activity against multiple lifecycle stages of the Plasmodium parasite [2].

Potential Target/Mechanism Of Action: As the precise mechanism of action in the malaria parasite is not yet known, we have not tagged a Plasmodium molecular target for this compound. Further information about possible mechanistic insights is provided under the Clinical data tab.