cannabidiol-dimethylheptyl (-)-CBD-DMH   Click here for help

GtoPdb Ligand ID: 10012

Synonyms: (-)-5'-CBD-DMH | (-)-5'-DMH-CBD | 1"',1'"-Dimethylheptylcannabidiol | 5-(1,1-Dimethylheptyl)cannabidiol | DMH-CBD
Compound class: Synthetic organic
Comment: Cannabidiol-dimethylheptyl (-)-CBD-DMH ((-)-5'-CBD-DMH) is a synthetic homologue of cannabidiol. Structurally the pentyl chain of cannabidiol has been replaced by a dimethylheptyl chain, and it retains the same stereochemistry as natural cannabidiol. Like cannabidiol (-)-5'-DMH-CBD is not psychotropic, has anticonvulsant activity, and is not a CB1 receptor agonist [2].

cannabidiol-dimethylheptyl (-)-CBD-DMH is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 40.46
Molecular weight 370.29
XLogP 8.86
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCCC(c1cc(O)c(c(c1)O)C1C=C(C)CCC1C(=C)C)(C)C
Isomeric SMILES CCCCCCC(c1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C)(C)C
InChI InChI=1S/C25H38O2/c1-7-8-9-10-13-25(5,6)19-15-22(26)24(23(27)16-19)21-14-18(4)11-12-20(21)17(2)3/h14-16,20-21,26-27H,2,7-13H2,1,3-6H3/t20-,21+/m0/s1
InChI Key MPJURNPNPDQYSY-LEWJYISDSA-N
References
1. Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, Moriello AS, Davis JB, Mechoulam R, Di Marzo V. (2001)
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
Br J Pharmacol, 134 (4): 845-52. [PMID:11606325]
2. Hanus LO, Tchilibon S, Ponde DE, Breuer A, Fride E, Mechoulam R. (2005)
Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors.
Org Biomol Chem, 3 (6): 1116-23. [PMID:15750656]