Synonyms: PPI-0903 | TAK-599 | Teflaro® | Zinforo®
ceftaroline fosamil is an approved drug (FDA (2010), EMA (2012))
Compound class:
Synthetic organic
Comment: Ceftaroline fosamil is a fifth-generation cephalosporin prodrug which is hydrolysed to the active form, ceftaroline, in vivo. It has anti-MRSA activity [1]. Ceftaroline was removed from the World Health Organization's List of Essential Medicines in 2019.
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References |
1. Duplessis C, Crum-Cianflone NF. (2011)
Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Clin Med Rev Ther, 3. [PMID:21785568] |
2. Ge Y, Biek D, Talbot GH, Sahm DF. (2008)
In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. Antimicrob Agents Chemother, 52 (9): 3398-407. [PMID:18625769] |
3. Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN. (2010)
Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Antimicrob Agents Chemother, 54 (6): 2716-9. [PMID:20308374] |