ceftaroline fosamil   Click here for help

GtoPdb Ligand ID: 10899

Synonyms: PPI-0903 | TAK-599 | Teflaro® | Zinforo®
Approved drug
ceftaroline fosamil is an approved drug (FDA (2010), EMA (2012))
Compound class: Synthetic organic
Comment: Ceftaroline fosamil is a fifth-generation cephalosporin prodrug which is hydrolysed to the active form, ceftaroline, in vivo. It has anti-MRSA activity [1]. Ceftaroline was removed from the World Health Organization's List of Essential Medicines in 2019.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 13
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 340.13
Molecular weight 684.01
XLogP 0.78
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCO/N=C(/c1nsc(n1)NP(=O)(O)O)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])Sc1scc(n1)c1cc[n+](cc1)C
Isomeric SMILES CCO/N=C(/c1nsc(n1)NP(=O)(O)O)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])Sc1scc(n1)c1cc[n+](cc1)C
InChI InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1
InChI Key ZCCUWMICIWSJIX-NQJJCJBVSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2010), EMA (2012))
IUPAC Name Click here for help
(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
International Nonproprietary Names Click here for help
INN number INN
8827 ceftaroline fosamil
Synonyms Click here for help
PPI-0903 | TAK-599 | Teflaro® | Zinforo®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Ceftaroline, Ceftaroline fosamil
Other databases
CAS Registry No. 229016-73-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL501122
DrugBank Ligand DB06590
DrugCentral Ligand 4169
GtoPdb PubChem SID 405560340
PubChem CID 9852981
Search Google for chemical match using the InChIKey ZCCUWMICIWSJIX-NQJJCJBVSA-N
Search Google for chemicals with the same backbone ZCCUWMICIWSJIX
Search PubMed clinical trials ceftaroline fosamil
Search PubMed titles ceftaroline fosamil
Search PubMed titles/abstracts ceftaroline fosamil
UniChem Compound Search for chemical match using the InChIKey ZCCUWMICIWSJIX-NQJJCJBVSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZCCUWMICIWSJIX-NQJJCJBVSA-N