- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: Aczone® | NSC-6091
dapsone is an approved drug (FDA (1979), UK (1988))
Compound class: Synthetic organic
Comment: Dapsone is a sulfonamide-related antibacterial, antimalarial and anti-inflammatory drug. In bacteria it inhibits dihydropteroate synthase-mediated production of folic acid, which has the effect of disrupting the availability of thymidylate for DNA synthesis.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Barr J. (2011)
A short history of dapsone, or an alternative model of drug development.
J Hist Med Allied Sci, 66 (4): 425-67. [PMID:20966036]
2. Luzzatto L. (2010)
The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.
Lancet, 376 (9742): 739-41. [PMID:20599264]
3. Petersen E. (2004)
Malaria chemoprophylaxis: when should we use it and what are the options?.
Expert Rev Anti Infect Ther, 2 (1): 119-32. [PMID:15482177]
4. Queener SF. (1995)
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
J Med Chem, 38 (24): 4739-59. [PMID:7490723]
5. Zhang Y, Meshnick SR. (1991)
Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs.
Antimicrob Agents Chemother, 35 (2): 267-71. [PMID:2024960]