Abbreviated name: DRV
Synonyms: Prezista® | TMC114 | UIC-94017
darunavir is an approved drug (FDA (2006), EMA (2007))
Compound class:
Synthetic organic
Comment: Darunavir is a second-generation human immunodeficiency virus 1 (HIV-1) protease inhibitor (PI) [2].
![]() View more information in the IUPHAR Pharmacology Education Project: darunavir |
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References |
1. Chen J, Xia L, Liu L, Xu Q, Ling Y, Huang D, Huang W, Song S, Xu S, Shen Y et al.. (2020)
Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19. Open Forum Infect Dis, 7 (7): ofaa241. [PMID:32671131] |
2. Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y et al.. (2003)
Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother, 47 (10): 3123-9. [PMID:14506019] |