Abbreviated name: DRV
Synonyms: Prezista® | TMC114 | UIC-94017
darunavir is an approved drug (FDA (2006), EMA (2007))
Compound class:
Synthetic organic
Comment: Darunavir is a second-generation human immunodeficiency virus 1 (HIV-1) protease inhibitor (PI) [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: darunavir |
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No information available. |
Summary of Clinical Use |
Darunavir is used in the treatment of HIV-1 infection and for postexposure prophylaxis (off-label). To increase its bioavailability and half-life, darunavir is coadministered with other antiretroviral agents such as ritonavir or cobicistat. The compound is also approved as a component of Symtuza®, a once daily anti-HIV therapy that contains darunavir, cobicistat, emtricitabine, and tenofovir alafenamide fumarate. SARS-CoV-2 and COVID-19: The antiviral activity and safety of darunavir/cobicistat for treating COVID-19 pneumonia has been evaluated in a Phase 3 clinical trial (NCT04252274). This trial found no significant benefit for patients with severe COVID-19, when compared to standard therapy [1]. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT04252274 | Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19 | Phase 3 Interventional | Shanghai Public Health Clinical Center |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) Drugs.com European Medicines Agency (EMA) |