Synonyms: GS-4104 | GS4104 | RO-640796 | RO640796 | Tamiflu® | Tamvir®
oseltamivir is an approved drug (FDA (1999), EMA (2002))
Compound class:
Synthetic organic
Comment: Oseltamivir is an oral antiviral prodrug. Its active metabolite inhibits influenza neuraminidases and prevents new viral particles from being released from infected host cells.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T. (2008)
Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. Antimicrob Agents Chemother, 52 (10): 3484-91. [PMID:18694948] |
2. Hou B, Liu Z, Yang XB, Zhu WF, Li JY, Yang L, Reng FC, Lv YF, Hu JM, Liao GY et al.. (2019)
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases. Bioorg Med Chem, 27 (17): 3846-3852. [PMID:31324565] |
3. Richards MR, Guo T, Hunter CD, Cairo CW. (2018)
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. Bioorg Med Chem, 26 (19): 5349-5358. [PMID:29903413] |