H3 14s18 stapled B-chain   Click here for help

GtoPdb Ligand ID: 11910

Comment: This peptide is a stapled relaxin-3 mimetic [1-2]. It is a synthetic helical analogue of the relaxin-3 B chain. The hydrocarbon bond (staple) forms between the (S)2-(4′-pentenyl)alanine residues at positions 14 and 18.
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1. Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. (2016)
Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Peptides, 84: 44-57. [PMID:27498038]
2. Marwari S, Poulsen A, Shih N, Lakshminarayanan R, Kini RM, Johannes CW, Dymock BW, Dawe GS. (2019)
Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats.
Br J Pharmacol, 176 (20): 3899-3923. [PMID:31220339]