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Compound class:
Peptide or derivative
Comment: This peptide is a stapled relaxin-3 mimetic [1-2]. It is a synthetic helical analogue of the relaxin-3 B chain. The hydrocarbon bond (staple) forms between the (S)2-(4′-pentenyl)alanine residues at positions 14 and 18.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. (2016)
Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity. Peptides, 84: 44-57. [PMID:27498038] |
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2. Marwari S, Poulsen A, Shih N, Lakshminarayanan R, Kini RM, Johannes CW, Dymock BW, Dawe GS. (2019)
Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats. Br J Pharmacol, 176 (20): 3899-3923. [PMID:31220339] |
