[3H]GR 125,743

Ligand id: 131

Name: [3H]GR 125,743    

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 57.7
Molecular weight 416.22
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Grånäs C, Larhammar D. (1999)
Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.
Eur. J. Pharmacol., 380 (2-3): 171-81. [PMID:10513577]
2. Xie Z, Lee SP, O'Dowd BF, George SR. (1999)
Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
FEBS Lett., 456 (1): 63-7. [PMID:10452531]