[3H]GR 125,743

Ligand id: 131

Name: [3H]GR 125,743    

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 57.7
Molecular weight 416.22
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT1B receptor Hs Antagonist Antagonist 8.6 – 9.2 pKd - 1-2
pKd 8.6 – 9.2 (Kd 2.6x10-9 – 7.1x10-10 M) [1-2]
5-HT1D receptor Hs Antagonist Antagonist 8.6 pKd - 2
pKd 8.6 (Kd 2.8x10-9 M) [2]