mescaline   Click here for help

GtoPdb Ligand ID: 13139

Synonyms: 3,4,5-Trimethoxyphenethylamine | mescalin | mezcalin | Tmpea
Compound class: Natural product or derivative
Comment: Mescaline is the only confirmed hallucinogenic phenethylamine that exists in nature. It is found in cacti including Peyote and Trichocereus (Echinopsis) species. Pharmacologically it acts as an agonist at central 5-HT2A receptors.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 53.71
Molecular weight 211.26
XLogP 0.5
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COC1=CC(=CC(=C1OC)OC)CCN
Isomeric SMILES COC1=CC(=CC(=C1OC)OC)CCN
InChI InChI=1S/C11H17NO3/c1-13-9-6-8(4-5-12)7-10(14-2)11(9)15-3/h6-7H,4-5,12H2,1-3H3
InChI Key RHCSKNNOAZULRK-UHFFFAOYSA-N
References
1. Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. (2003)
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
J Med Chem, 46 (16): 3526-35. [PMID:12877591]
2. Glennon RA, Liebowitz SM, Anderson 3rd GM. (1980)
Serotonin receptor affinities of psychoactive phenalkylamine analogues.
J Med Chem, 23 (3): 294-9. [PMID:7365744]
3. Ley L, Holze F, Arikci D, Becker AM, Straumann I, Klaiber A, Coviello F, Dierbach S, Thomann J, Duthaler U et al.. (2023)
Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants.
Neuropsychopharmacology, 48 (11): 1659-1667. [PMID:37231080]
4. Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, Nichols DE. (1997)
Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.
J Med Chem, 40 (19): 2997-3008. [PMID:9301661]