H+   Click here for help

GtoPdb Ligand ID: 2346

Synonyms: hydrogen ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Coulter KL, Périer F, Radeke CM, Vandenberg CA. (1995)
Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.
Neuron, 15 (5): 1157-68. [PMID:7576658]
2. Doi T, Fakler B, Schultz JH, Schulte U, Brändle U, Weidemann S, Zenner HP, Lang F, Ruppersberg JP. (1996)
Extracellular K+ and intracellular pH allosterically regulate renal Kir1.1 channels.
J Biol Chem, 271 (29): 17261-6. [PMID:8663367]
3. Hughes BA, Kumar G, Yuan Y, Swaminathan A, Yan D, Sharma A, Plumley L, Yang-Feng TL, Swaroop A. (2000)
Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel.
Am J Physiol, Cell Physiol, 279 (3): C771-84. [PMID:10942728]
4. Jiang J, Li M, Yue L. (2005)
Potentiation of TRPM7 inward currents by protons.
J Gen Physiol, 126 (2): 137-50. [PMID:16009728]
5. Pessia M, Imbrici P, D'Adamo MC, Salvatore L, Tucker SJ. (2001)
Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1.
J Physiol (Lond.), 532 (Pt 2): 359-67. [PMID:11306656]
6. Qu Z, Yang Z, Cui N, Zhu G, Liu C, Xu H, Chanchevalap S, Shen W, Wu J, Li Y et al.. (2000)
Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domains.
J Biol Chem, 275 (41): 31573-80. [PMID:10896660]
7. Sackin H, Vasilyev A, Palmer LG, Krambis M. (2003)
Permeant cations and blockers modulate pH gating of ROMK channels.
Biophys J, 84 (2 Pt 1): 910-21. [PMID:12547773]
8. Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. (2016)
Copper and protons directly activate the zinc-activated channel.
Biochem Pharmacol, 103: 109-17. [PMID:26872532]
9. Tsai TD, Shuck ME, Thompson DP, Bienkowski MJ, Lee KS. (1995)
Intracellular H+ inhibits a cloned rat kidney outer medulla K+ channel expressed in Xenopus oocytes.
Am J Physiol, 268 (5 Pt 1): C1173-8. [PMID:7762610]
10. Tucker SJ, Imbrici P, Salvatore L, D'Adamo MC, Pessia M. (2000)
pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia.
J Biol Chem, 275 (22): 16404-7. [PMID:10764726]
11. Zhu G, Chanchevalap S, Cui N, Jiang C. (1999)
Effects of intra- and extracellular acidifications on single channel Kir2.3 currents.
J Physiol (Lond.), 516 ( Pt 3): 699-710. [PMID:10200419]