H+

Ligand id: 2346

Name: H+

Natural/Endogenous Targets
Target
ASIC1
ASIC2
ASIC3
glycine receptor α1 subunit
ZAC
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir2.4 Hs Gating inhibitor (Extracellular H+) Antagonist 7.1 pKi - 3
pKi 7.1 [3]
Voltage: -120.0 mV
Kir2.3 Hs Gating inhibitor (Extracellular H+) Antagonist 6.7 – 7.4 pKi - 1,5,10
pKi 6.7 – 7.4 [1,10]
Voltage: -120.0 – -100.0 mV
pKi 6.8 – 6.8 [5,10]
Voltage: -150.0 – 100.0 mV
Kir4.2 Rn Gating inhibitor (Intracellular H+) Antagonist 6.7 – 7.1 pEC50 - 4
pEC50 6.7 – 7.1 [4]
Voltage: -100.0 mV
Kir4.1 Rn Gating inhibitor (Intracellular H+) Antagonist 6.0 – 6.1 pEC50 - 4,9
pEC50 6.0 – 6.1 [4,9]
Voltage: -100.0 mV
ASIC1 Hs Activator (Extracellular H+) - ~5.1 – 6.8 pEC50 -
pEC50 ~6.2 – 6.8 (EC50 ~6.3x10-7 – 1.6x10-7 M) ASIC1a
pEC50 ~5.1 – 6.2 (EC50 ~8x10-6 – 6.3x10-7 M) ASIC1b
ZAC Hs Agonist Agonist 5.6 pEC50 - 7
pEC50 5.6 [7]
TRPV1 Hs Activator (extracellular H+) - 5.4 pEC50 -
pEC50 5.4 (EC50 3.98x10-6 M) at 37°C
ASIC3 Hs Activator (Extracellular H+) - ~3.5 – 6.7 pEC50 -
pEC50 ~6.2 – 6.7 (EC50 ~6.3x10-7 – 2x10-7 M) transient component
pEC50 ~3.5 – 4.3 (EC50 ~3.5x10-4 – 5x10-5 M) sustained component
ASIC2 Hs Activator (Extracellular H+) - ~4.1 – 5.0 pEC50 -
pEC50 ~4.1 – 5.0 (EC50 ~8x10-5 – 1x10-5 M)
Kir1.1 Rn Gating inhibitor (Intracellular H+) Antagonist 6.8 pIC50 - 2,6,8
pIC50 6.8 [2,6,8]
Voltage: -160.0 – -40.0 mV
TRPM5 Hs Channel blocker (Extracellular H+) - 3.2 pIC50 -
pIC50 3.2 (IC50 6.3x10-4 M)
glycine receptor α1 subunit Hs Allosteric modulator (Extracellular H+) Inhibition - - -
endogenous
TRPC6 Hs Channel blocker (Extracellular H+) - - - -
TRPM2 Hs Channel blocker (extracellular H+) - - - -
TRPM6 Hs Activator (extracellular H+) Potentiation - - -
μM range
TRPM7 Hs Activator (Extracellular H+) Potentiation - - -