cyclic GMP

Ligand id: 2347

Name: cyclic GMP

Abbreviated name: cGMP

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 1
Topological polar surface area 184.62
Molecular weight 345.05
XLogP -2.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bradley J, Li J, Davidson N, Lester HA, Zinn K. (1994)
Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP.
Proc. Natl. Acad. Sci. U.S.A., 91 (19): 8890-4. [PMID:7522325]
2. Chen TY, Illing M, Molday LL, Hsu YT, Yau KW, Molday RS. (1994)
Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation.
Proc. Natl. Acad. Sci. U.S.A., 91 (24): 11757-61. [PMID:7526403]
3. Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J. (1992)
Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.
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4. Dryja TP, Finn JT, Peng YW, McGee TL, Berson EL, Yau KW. (1995)
Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.
Proc. Natl. Acad. Sci. U.S.A., 92 (22): 10177-81. [PMID:7479749]
5. Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC. (2000)
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.
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6. Finn JT, Krautwurst D, Schroeder JE, Chen TY, Reed RR, Yau KW. (1998)
Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.
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7. Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB. (1998)
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.
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8. Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB. (1998)
Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.
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9. Fujishige K, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K, Omori K. (1999)
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).
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10. Gardner C, Robas N, Cawkill D, Fidock M. (2000)
Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase.
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11. Gordon SE, Zagotta WN. (1995)
A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors.
Neuron, 14 (1): 177-83. [PMID:7530019]
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Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase.
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13. Lee HM, Park YS, Kim W, Park CS. (2001)
Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes.
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14. Liman ER, Buck LB. (1994)
A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP.
Neuron, 13 (3): 611-21. [PMID:7522482]
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A family of hyperpolarization-activated mammalian cation channels.
Nature, 393 (6685): 587-91. [PMID:9634236]
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Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
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17. Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, Bönigk W, Seifert R, Biskup C, Schwede F et al.. (2012)
Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.
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C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating.
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19. Peng C, Rich ED, Thor CA, Varnum MD. (2003)
Functionally important calmodulin-binding sites in both NH2- and COOH-terminal regions of the cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit.
J. Biol. Chem., 278 (27): 24617-23. [PMID:12730238]
20. Wissinger B, Müller F, Weyand I, Schuffenhauer S, Thanos S, Kaupp UB, Zrenner E. (1997)
Cloning, chromosomal localization and functional expression of the gene encoding the alpha-subunit of the cGMP-gated channel in human cone photoreceptors.
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21. Yu WP, Grunwald ME, Yau KW. (1996)
Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide-gated ion channel of retinal cone photoreceptors.
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22. Zheng J, Trudeau MC, Zagotta WN. (2002)
Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit.
Neuron, 36 (5): 891-6. [PMID:12467592]