cyclic GMP

Ligand id: 2347

Name: cyclic GMP

Abbreviated name: cGMP

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 1
Topological polar surface area 184.62
Molecular weight 345.05
XLogP -2.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Target
phosphodiesterase 2A
phosphodiesterase 3A
phosphodiesterase 3B
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CNGA3 Rn Activator Agonist 5.5 pKd - 13
pKd 5.5 [13]
Voltage: -80.0 – 80.0 mV
CNGA3 Hs Activator Agonist 4.7 – 5.6 pKd - 19-21
pKd 4.7 – 5.6 [19-21]
Voltage: -60.0 – 80.0 mV
HCN2 Mm Activator Agonist 5.2 pKi - 15
pKi 5.2 [15]
Voltage: -40.0 mV
CNGA1 Hs Activator Agonist 4.1 – 4.2 pKi - 2-4,6,11,18,22
pKi 4.1 – 4.2 (Ki 8.5x10-5 – 6x10-5 M) [2-4,6,11,18,22]
Voltage: -60.0 – 60.0 mV
CNGA2 Rn Activator Agonist 5.6 – 5.8 pEC50 - 1,14,17
pEC50 5.6 – 5.8 (EC50 2.5x10-6 – 1.74x10-6 M) [1,14,17]
Voltage: -80.0 – 100.0 mV
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphodiesterase 2A Hs Activator Activation - - -
phosphodiesterase 3A Hs Inhibitor Inhibition - - -
phosphodiesterase 3B Hs Inhibitor Inhibition - - -
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
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