Synonyms: MK-801
Compound class:
Synthetic organic
Comment: Dizocilpine (MK-801) is a NMDA receptor antagonist (channel blocker).
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Brennan BP, Roberts JL, Fogarty KV, Reynolds KA, Jonas JM, Hudson JI. (2008)
Memantine in the treatment of binge eating disorder: an open-label, prospective trial. Int J Eat Disord, 41 (6): 520-6. [PMID:18433015] |
2. Deng SN, Yan YH, Zhu TL, Ma BK, Fan HR, Liu YM, Li WG, Li F. (2019)
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating. Front Psychiatry, 10: 15. [PMID:30800078] |
3. Kofuji P, Hofer M, Millen KJ, Millonig JH, Davidson N, Lester HA, Hatten ME. (1996)
Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Neuron, 16 (5): 941-52. [PMID:8630252] |
4. Stanley BG, Willett 3rd VL, Donias HW, Dee 2nd MG, Duva MA. (1996)
Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. Am J Physiol, 270 (2 Pt 2): R443-9. [PMID:8779877] |