H2O2   Click here for help

GtoPdb Ligand ID: 2448

Synonyms: hydrogen peroxide
Compound class: Inorganic
Comment: At high concentrations H2O2 is toxic and damages cells, but at low levels it modulates some important physiological processes, including signaling in cell proliferation, apoptosis, carbohydrate metabolism, and platelet activation. Catalase is the main H2O2-degrading enzyme in mammalian cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Andersson DA, Gentry C, Moss S, Bevan S. (2008)
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress.
J Neurosci, 28 (10): 2485-94. [PMID:18322093]
2. Fonfria E, Marshall IC, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, McNulty S. (2004)
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase.
Br J Pharmacol, 143 (1): 186-92. [PMID:15302683]
3. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J et al.. (2002)
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
Mol Cell, 9 (1): 163-73. [PMID:11804595]
4. Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, Schultz G, Harteneck C. (2004)
Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.
Am J Physiol, Cell Physiol, 286 (1): C129-37. [PMID:14512294]
5. Sawada Y, Hosokawa H, Matsumura K, Kobayashi S. (2008)
Activation of transient receptor potential ankyrin 1 by hydrogen peroxide.
Eur J Neurosci, 27 (5): 1131-42. [PMID:18364033]
6. Smith MA, Herson PS, Lee K, Pinnock RD, Ashford ML. (2003)
Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.
J Physiol (Lond.), 547 (Pt 2): 417-25. [PMID:12562896]
7. Wehage E, Eisfeld J, Heiner I, Jüngling E, Zitt C, Lückhoff A. (2002)
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.
J Biol Chem, 277 (26): 23150-6. [PMID:11960981]