H2O2   Click here for help

GtoPdb Ligand ID: 2448

Synonyms: hydrogen peroxide
Compound class: Inorganic
Comment: At high concentrations H2O2 is toxic and damages cells, but at low levels it modulates some important physiological processes, including signaling in cell proliferation, apoptosis, carbohydrate metabolism, and platelet activation. Catalase is the main H2O2-degrading enzyme in mammalian cells.
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
thyroid peroxidase
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM2 Ligand is endogenous in the given species Hs Activator Agonist - - 5x10-7 - 5x10-5 2-4,6-7
Conc range: 5x10-7 - 5x10-5 M [2-4,6-7]
Voltage: Physiological
TRPA1 Ligand is endogenous in the given species Mm Activator Activation 3.6 pEC50 - 1,5
pEC50 3.6 [1,5]
Description: Calcium imaging
Conditions: CHO cells expressing mouse TRPA1 loaded with Fura-2
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields