Ligand id: 347

Name: strychnine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 32.78
Molecular weight 334.17
XLogP 0.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Jakubik J, Bacakova L, El-Fakahany EE, Tucek S. (1997)
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic receptors.
Mol. Pharmacol., 52: 172-179. [PMID:9224827]
2. Lazareno S, Birdsall NJM. (1995)
Detection, quantitation and verification of allosteric interactions of agents with labelled and unlabelled ligands at G protein-coupled receptors, interactions of strychnine and acetylcholine at muscarinic receptors.
Mol. Pharmacol., 48: 362-378. [PMID:7651370]
3. Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJ, Mohr K. (2003)
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Mol Pharmacol, 64: 180-190. [PMID:12815174]