strychnine

Ligand id: 347

Name: strychnine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 32.78
Molecular weight 334.17
XLogP 0.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Strychnine is an antagonist of glycine receptors and an allosteric modulator of muscarinic acetylcholine receptors.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M1 receptor Hs Allosteric modulator Neutral 4.9 – 5.0 pKd - 1-2
pKd 4.9 – 5.0 [1-2]
M2 receptor Hs Allosteric modulator Positive 4.9 – 5.0 pKd - 1-3
pKd 4.9 – 5.0 [1-3]
M3 receptor Hs Allosteric modulator Negative 4.2 – 5.7 pKd - 1-2
pKd 4.2 – 5.7 [1-2]
M1 receptor Hs Allosteric modulator Negative 4.9 pKd - 2
pKd 4.9 [2]
M4 receptor Hs Allosteric modulator Positive 4.8 – 5.0 pKd - 1-2
pKd 4.8 – 5.0 [1-2]
M5 receptor Hs Allosteric modulator Negative 3.6 pKd - 2
pKd 3.6 [2]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
glycine receptor α1 subunit Hs Antagonist Antagonist - - -
glycine receptor α2 subunit Hs Antagonist Antagonist - - -
glycine receptor α3 subunit Hs Antagonist Antagonist - - -
nicotinic acetylcholine receptor α9 subunit Hs Antagonist Antagonist - - -
α9α10
(α9)5
nicotinic acetylcholine receptor α10 subunit Hs Antagonist Antagonist - - -
α9α10
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields