Ligand id: 3622

Name: N-palmitoylethanolamine

Abbreviated name: PEA

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 17
Topological polar surface area 49.33
Molecular weight 299.28
XLogP 6.65
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M et al.. (2006)
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.
Cell Metab., 3 (3): 167-75. [PMID:16517404]
2. Ryberg E, Larsson N, Sj√∂gren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. (2007)
The orphan receptor GPR55 is a novel cannabinoid receptor.
Br. J. Pharmacol., 152 (7): 1092-101. [PMID:17876302]
3. Ueda N, Yamanaka K, Yamamoto S. (2001)
Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance.
J. Biol. Chem., 276 (38): 35552-7. [PMID:11463796]
4. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006)
A second fatty acid amide hydrolase with variable distribution among placental mammals.
J. Biol. Chem., 281 (48): 36569-78. [PMID:17015445]