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Synonyms: 5-fluoro-2'-deoxyuridine | floxidine | FUDR®
floxuridine is an approved drug (FDA (1970))
Compound class:
Synthetic organic
Comment: Floxuridine is metabolized to 5-fluorouracil when given by rapid injection, but is converted to floxuridine monophosphate when given as continuous infusion. 5-fluorouracil is considered the active drug.
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References |
1. Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. (2005)
Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem, 280 (16): 15880-7. [PMID:15701636] |