floxuridine   Click here for help

GtoPdb Ligand ID: 4801

Synonyms: 5-fluoro-2'-deoxyuridine | floxidine | FUDR®
Approved drug
floxuridine is an approved drug (FDA (1970))
Compound class: Synthetic organic
Comment: Floxuridine is metabolized to 5-fluorouracil when given by rapid injection, but is converted to floxuridine monophosphate when given as continuous infusion. 5-fluorouracil is considered the active drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 104.55
Molecular weight 246.07
XLogP -0.66
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OCC1OC(CC1O)n1cc(F)c(=O)[nH]c1=O
Isomeric SMILES OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O
InChI InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI Key ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1970))
Is prodrug? Yes
Active form 5-fluorouracil
IUPAC Name Click here for help
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
International Nonproprietary Names Click here for help
INN number INN
2010 floxuridine
Synonyms Click here for help
5-fluoro-2'-deoxyuridine | floxidine | FUDR®
Database Links Click here for help
CAS Registry No. 50-91-9 (source: Scifinder)
ChEMBL Ligand CHEMBL917
DrugBank Ligand DB00322
DrugCentral Ligand 1184
GtoPdb PubChem SID 178101503
PubChem CID 5790
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UniChem Compound Search for chemical match using the InChIKey ODKNJVUHOIMIIZ-RRKCRQDMSA-N
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Wikipedia Floxuridine

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Tocris
Floxuridine (links to external site)
Cat. No. 4659