tumour necrosis factor membrane form   Click here for help

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Immunopharmacology Ligand
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species: Human
1. Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J, MacDonald TT, Ray KP et al.. (2018)
Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease.
Sci Rep, 8 (1): 4941. [PMID:29563546]