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Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Compound class: Endogenous peptide in human, mouse or rat
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
1. Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J, MacDonald TT, Ray KP et al.. (2018)
Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease.
Sci Rep, 8 (1): 4941. [PMID:29563546]