tumour necrosis factor membrane form   

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species: Human
Immunopharmacology Comments
The approved anti-TNF biologics adalimumab and infliximab bind the soluble form of TNF- α and also inhibit the TNF-α-induced response mediated by the membrane anchored form of the cytokine [1].