tumour necrosis factor membrane form   Click here for help

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species: Human
Peptide Sequence Click here for help
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSS
SRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA
VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Selected 3D Structures
PDB Id: 1TNF
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
Predicted phosphorylation of serine residue at position 2; residues 19 and 20 are N6-myristoyl lysine