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Synonyms: 2,6-diisopropylphenol | Diprivan® | ICI 35868
propofol is an approved drug (FDA (1989))
Compound class: Synthetic organic
Comment: Propofol is a short-acting (lasting 5-10 minutes) sedative.
Propofol is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: propofol
1. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. (2005)
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.
J. Pharmacol. Exp. Ther., 315 (2): 517-25. [PMID:16033909]
2. Lyashchenko AK, Redd KJ, Yang J, Tibbs GR. (2007)
Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.
J. Physiol. (Lond.), 583 (Pt 1): 37-56. [PMID:17569731]
3. Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS et al.. (2013)
A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Nat. Chem. Biol., 9 (11): 715-20. [PMID:24056400]