Ligand id: 5464

Name: propofol

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 178.14
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
As the GABAA binding site was reported to exist on both β3 homopentamers and α1β3 heteropentamers [3] we have not tagged a primary drug target for propofol.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
HCN1 Mm Channel blocker - 5.2 pIC50 - 1-2
pIC50 5.2 [1-2]
Voltage: -40.0 mV
Ligand mentioned in the following text fields