Zn2+   Click here for help

GtoPdb Ligand ID: 566

Synonyms: zinc | zinc ion
Compound class: Inorganic
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References
1. Andersson DA, Gentry C, Moss S, Bevan S. (2009)
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
Proc Natl Acad Sci USA, 106 (20): 8374-9. [PMID:19416844]
2. Bloomenthal AB, Goldwater E, Pritchett DB, Harrison NL. (1994)
Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.
Mol Pharmacol, 46 (6): 1156-9. [PMID:7808436]
3. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. (2004)
Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.
J Neurosci, 24 (40): 8678-89. [PMID:15470133]
4. Coulter KL, Périer F, Radeke CM, Vandenberg CA. (1995)
Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.
Neuron, 15 (5): 1157-68. [PMID:7576658]
5. Davies PA, Wang W, Hales TG, Kirkness EF. (2003)
A novel class of ligand-gated ion channel is activated by Zn2+.
J Biol Chem, 278 (2): 712-7. [PMID:12381728]
6. Gill CH, Peters JA, Lambert JJ. (1995)
An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells.
Br J Pharmacol, 114 (6): 1211-21. [PMID:7620711]
7. Goytain A, Quamme GA. (2005)
Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters.
Physiol Genomics, 21 (3): 337-42. [PMID:15713785]
8. Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. (2007)
GPR39 signaling is stimulated by zinc ions but not by obestatin.
Endocrinology, 148: 13-20. [PMID:16959833]
9. Hu H, Bandell M, Petrus MJ, Zhu MX, Patapoutian A. (2009)
Zinc activates damage-sensing TRPA1 ion channels.
Nat Chem Biol, 5 (3): 183-90. [PMID:19202543]
10. Hubbard PC, Lummis SC. (2000)
Zn(2+) enhancement of the recombinant 5-HT(3) receptor is modulated by divalent cations.
Eur J Pharmacol, 394 (2-3): 189-97. [PMID:10771284]
11. Jiang Q, Papasian CJ, Wang JQ, Xiong ZG, Chu XP. (2010)
Inhibitory regulation of acid-sensing ion channel 3 by zinc.
Neuroscience, 169 (2): 574-83. [PMID:20580786]
12. Krishek BJ, Moss SJ, Smart TG. (1998)
Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors.
J Physiol (Lond.), 507 ( Pt 3): 639-52. [PMID:9508826]
13. Laube B, Kuhse J, Rundström N, Kirsch J, Schmieden V, Betz H. (1995)
Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.
J Physiol (Lond.), 483 ( Pt 3): 613-9. [PMID:7776247]
14. Lynch JW, Jacques P, Pierce KD, Schofield PR. (1998)
Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.
J Neurochem, 71 (5): 2159-68. [PMID:9798943]
15. Miller PS, Beato M, Harvey RJ, Smart TG. (2005)
Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition.
J Physiol (Lond.), 566 (Pt 3): 657-70. [PMID:15905212]
16. Miller PS, Da Silva HM, Smart TG. (2005)
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
J Biol Chem, 280 (45): 37877-84. [PMID:16144831]
17. Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp M, Biebermann H. (2013)
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.
PLoS ONE, 8 (1): e53347. [PMID:23335960]
18. Osteen JD, Mindell JA. (2008)
Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition.
Biophys J, 95 (10): 4668-75. [PMID:18658230]
19. Swaminath G, Lee TW, Kobilka B. (2003)
Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor.
J Biol Chem, 278 (1): 352-6. [PMID:12409304]
20. Swaminath G, Steenhuis J, Kobilka B, Lee TW. (2002)
Allosteric modulation of beta2-adrenergic receptor by Zn(2+).
Mol Pharmacol, 61 (1): 65-72. [PMID:11752207]
21. Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. (2016)
Copper and protons directly activate the zinc-activated channel.
Biochem Pharmacol, 103: 109-17. [PMID:26872532]
22. Wiemer AJ, Tong H, Swanson KM, Hohl RJ. (2007)
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
Biochem Biophys Res Commun, 353 (4): 921-5. [PMID:17208200]
23. Zhang X, Bursulaya B, Lee CC, Chen B, Pivaroff K, Jegla T. (2009)
Divalent cations slow activation of EAG family K+ channels through direct binding to S4.
Biophys J, 97 (1): 110-20. [PMID:19580749]